Pepcid (Famotidine) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Pepcid (famotidine): H2 blocker for heartburn/GERD and ulcers. OTC/Rx dosing, onset, interactions, side effects, and prices by country. Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [4] Pepcid is a histamine-2 blocker that works by decreasing the amount of acid the stomach produces. Pepcid is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. What do Pepcid products treat? Pepcid products are commonly used to prevent and treat heartburn caused by acid indigestion and upset stomach. PEPCID® is the original famotidine brand and, for 35 years, has been effective and safe acid reducer when used as directed. PEPCID® is clinically proven to provide heartburn relief and is backed by 50+ clinical studies. Dr. Tara Narula debunked the viral over-the-counter combination of antihistamines and Pepcid that some are using to treat menopause symptoms. Famotidine (Pepcid) is a type of acid reducer called a histamine-2 (H2) antagonist. It helps treat problems caused by too much stomach acid. Over-the-counter famotidine (Pepcid or Pepcid AC) can help with heartburn in people who are 12 and up. Famotidine is used to treat stomach ulcers (gastric and duodenal), erosive esophagitis (heartburn or acid indigestion), and gastroesophageal reflux disease (GERD). GERD is a condition where the acid in the stomach washes back up into the esophagus. It’s prescribed for conditions such as gastroesophageal reflux disease (GERD). It comes as a generic drug and as the brand-name drug Pepcid. Learn about side effects, warnings, and dosage.